Royal Air Force Typhoon FGR4s have conducted a mission with France's air force in a joint strike on an underground arms cache in Syrian territory employed by the IS group, per a report from the UK's MoD.
The facility, pinpointed through surveillance, was assessed as containing munitions and bombs, the release indicated, and was located in hills just above the ancient city of Palmyra in Syria's central region.
"Our fighter planes used precision-guided Paveway IV munitions to target a series of approach shafts leading to the depot... initial indications are that the objective was successfully hit," the MoD said.
There was no evidence of any civilian casualties in the strike conducted Saturday night and all the aircraft returned to base without incident, the ministry further stated.
The British jets were backed up by a Voyager tanker plane.
IS - referred to as the so-called Islamic State - imposed militant control over parts of both Syria and Iraq until 2019.
"This action underscores our UK leadership, and determination to stand shoulder to shoulder with our partners, to eradicate any revival of the terrorist group and their dangerous and violent ideologies in the region," the British Defence Secretary the minister said.
RAF aircraft have carried out patrols over Syrian airspace to "prevent any efforts to regroup" of the group after its defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I must thank every member of our armed forces involved in this operation for their skill and their bravery," he said. "They were among a great many UK service members deployed over Christmas and New Year. This action, to take out terrorist threats who pose a risk to our security, highlights how our armed forces are prepared to act, continuously, keeping Britain secure domestically and strong abroad."
In December, the US military executed what it termed a "massive strike" on IS targets in the country, following an assault resulted in the deaths of two US servicemembers and a civilian linguist in the Palmyra area.
The United Nations says IS still has roughly 5-7 thousand militants in both countries.